|Summary||A synthetic opioid analgesic, tramadol is used to treat moderate pain and can be considered a medium-strength opioid. Tramadol also has the unusual effect of being a serotonin releasing agent and a serotonin reuptake inhibitor, and as a consequence should not be taken in excess due to the risk of serotonin syndrome. Risk of seizures above 300mg doses.|
|Dose||Oral Light: 50-100mg Common: 100-250mg Heavy: 250-400mg |
NOTE: Tramadol has a ceiling dose, where recreational effects are not increased. Risk of seizure at doses over 300mg. Tramadol decreases the seizure threshold, use extreme caution. Dosing insufflated is ineffective.
|Onset||1 hour first effects, reaching peak blood concentration at 4 hours.|
|Effects||euphoria, elevated mood, overall feeling of contentedness, itching, drowsiness, vomiting, urinary retention, nausea, constipation, risk of seizure above 300mg|
|Avoid||benzos, alcohol, and other opiates|
|Bioavailability||Oral 68-72% | Rectal 77%|