{"err":null,"data":[{"aliases":["diamorphine"],"categories":["opioid","habit-forming","depressant","common"],"dose_note":" Note: Heroin dose varies greatly depending on quality and tolerance.","formatted_aftereffects":{"_unit":"hours","value":"1-24"},"formatted_dose":{"Insufflated":{"Common":"20-35mg","Heavy":"50-75mg","Light":"7.5-20mg","Strong":"35-50mg"},"Intravenous":{"Common":"5-10mg","Strong":"8-15mg"},"Smoked":{"Common":"15-25mg","Heavy":"30-50mg","Light":"5-15mg"}},"formatted_duration":{"_unit":"hours","Insufflated":"3-6","Intravenous":"4-5","Smoked":"3-5"},"formatted_effects":["Euphoria","Dry Mouth","Mood lift","Itchiness","Relaxant","Constipation","Pupil Constriction","Analgesia"],"formatted_onset":{"_unit":"minutes","Insufflated":"10-15","Intravenous":"0-5","Smoked":"5-10"},"links":{"experiences":"https://www.erowid.org/experiences/subs/exp_Heroin.shtml"},"name":"heroin","pretty_name":"Heroin","properties":{"after-effects":"1-24 hours.","aliases":["diamorphine"],"bioavailability":"Oral 35% | Intramuscular 85%","categories":["opioid","habit-forming","depressant","common"],"dose":"Insufflated Light: 7.5-20mg Common: 20-35mg Strong: 35-50mg Heavy: 50-75mg  | Smoked Light: 5-15mg Common: 15-25mg Strong 20-30mg Heavy: 30-50mg | Intravenous Common: 5-10mg Strong: 8-15mg | Note: Heroin dose varies greatly depending on quality and tolerance.","duration":"Insufflated: 3-6 hours | IV: 4-5 hours | Smoked: 3-5 hours.","effects":"Euphoria, Dry Mouth, Mood lift, Itchiness, Relaxant, Constipation, Pupil Constriction, Analgesia.","half-life":"2-3 minutes","marquis":"Deep purplish red","onset":"Insufflated: 10-15 minutes | Smoked: 5-10 minutes | IV: 0-5 minutes","summary":"A powerful opioid derived from Morphine, with 2-4x its potency. Infamous for a high addiction potential and fatal respiratory depression in overdose, C. R. Alder Wright first synthesised this compound in 1874 trying to find a less addictive alternative to Morphine. In recent years, it has often been sold cut with the extremely potent fentanyl, causing a spike in overdose deaths."},"pweffects":{"Anxiety suppression":"https://psychonautwiki.org/wiki/Anxiety_suppression","Cognitive euphoria":"https://psychonautwiki.org/wiki/Cognitive_euphoria","Compulsive redosing":"https://psychonautwiki.org/wiki/Compulsive_redosing","Constipation":"https://psychonautwiki.org/wiki/Constipation","Cough suppression":"https://psychonautwiki.org/wiki/Cough_suppression","Difficulty urinating":"https://psychonautwiki.org/wiki/Difficulty_urinating","Internal hallucinations":"https://psychonautwiki.org/wiki/Internal_hallucinations","Itchiness":"https://psychonautwiki.org/wiki/Itchiness","Nausea":"https://psychonautwiki.org/wiki/Nausea","Pain relief":"https://psychonautwiki.org/wiki/Pain_relief","Physical euphoria":"https://psychonautwiki.org/wiki/Physical_euphoria","Pupil constriction":"https://psychonautwiki.org/wiki/Pupil_constriction","Respiratory depression":"https://psychonautwiki.org/wiki/Respiratory_depression","Sedation":"https://psychonautwiki.org/wiki/Sedation"},"sources":{"_general":["Disrupted white matter integrity in heroin dependence: a controlled study utilizing diffusion tensor imaging - http://www.ncbi.nlm.nih.gov/pubmed/18720268","The treatment of heroin addicts with dextromethorphan: a double-blind comparison of dextromethorphan with chlorpromazine - http://www.ncbi.nlm.nih.gov/pubmed/2187002","Effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and quipazine on heroin self-administration in rhesus monkeys - http://www.ncbi.nlm.nih.gov/pubmed/22836370","Heroin \"overdose\" death: contribution of drug-associated environmental cues - http://www.ncbi.nlm.nih.gov/pubmed/7200260","Methadone trials have proven successful in treating Heroin addiction - http://jamanetwork.com/journals/jama/article-abstract/656315","Heroin has been linked to reduction in testosterone and DHT levels - http://www.sciencedirect.com/science/article/pii/0300483X79900167"]}}]}