{"err":null,"data":[{"aliases":["lsd-25","acid","cid","lucy"],"categories":["psychedelic","common"],"combos":{"2c-t-x":{"status":"Low Risk & Synergy"},"2c-x":{"status":"Low Risk & Synergy"},"5-meo-xxt":{"status":"Low Risk & Synergy"},"alcohol":{"status":"Low Risk & Decrease"},"amphetamines":{"note":"Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences","status":"Caution"},"amt":{"status":"Low Risk & Synergy"},"benzodiazepines":{"status":"Low Risk & Decrease"},"caffeine":{"status":"Low Risk & No Synergy"},"cannabis":{"note":"Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.","status":"Caution"},"cocaine":{"note":"Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences","status":"Caution"},"dextromethorphan":{"status":"Low Risk & Synergy"},"dmt":{"status":"Low Risk & Synergy"},"dox":{"status":"Low Risk & Synergy"},"ghb/gbl":{"status":"Low Risk & Decrease"},"ketamine":{"status":"Low Risk & Synergy"},"lithium":{"note":"There is a large number of reports indicating a high seizure and psychosis risk from this combination.","sources":[{"author":"Sandeep M Nayak, Natalie Gukasyan, Frederick S Barrett , Earth Erowid , Fire Erowid , Roland R Griffiths","title":"Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports","url":"https://doi.org/10.1055/a-1524-2794"},{"author":"Erowid","title":"Erowid Interactions","url":"https://erowid.org/chemicals/lsd/lsd_interactions.shtml"},{"author":"freshboi88","title":"I Was Only on One Dose","url":"https://erowid.org/experiences/exp.php?ID=93681"},{"author":"YouWerentYouAnymore","title":"Brought My Worst Thoughts to Life","url":"https://erowid.org/experiences/exp.php?ID=110780"},{"author":"Otto Simonsson, Peper S. Hendricks, Richard Chambers, Walter Osika, Simon B. Goldberg","title":"Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics","url":"https://doi.org/10.1016/j.jad.2023.01.073"},{"author":"Edwards, C., Van Gerpen, S., & Anand, V.","title":"New-Onset Seizures in an Adolescent Following Use of LSD while on Low-Dose Lithium Therapy: A Case Study. (2024)","url":"https://doi.org/10.1177%2F1941874414528939"}],"status":"Dangerous"},"maois":{"status":"Low Risk & Decrease"},"mdma":{"status":"Low Risk & Synergy"},"mescaline":{"status":"Low Risk & Synergy"},"mushrooms":{"status":"Low Risk & Synergy"},"mxe":{"status":"Low Risk & Synergy"},"nbomes":{"sources":[{"author":"Umemura, Y., Andrew, T. A., Jacobs, V. L., Giustini, A. J., Lewis, L. D., & Filiano, J. J.","title":"Fatal 251-NBOMe Intoxication: A New Recreational Risk. Academic Forensic Pathology","url":"https://doi.org/10.23907/2015.009"}],"status":"Low Risk & Synergy"},"nitrous":{"status":"Low Risk & Synergy"},"opioids":{"status":"Low Risk & No Synergy"},"pcp":{"status":"Low Risk & Synergy"},"ssris":{"status":"Low Risk & Decrease"},"tramadol":{"note":"Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.","status":"Unsafe"}},"dose_note":" Note: These doses are for pure LSD, note that tabs are often rather a lot weaker than they are advertised.","formatted_aftereffects":{"_unit":"hours","value":"12-24"},"formatted_dose":{"Oral":{"Common":"100-150ug","Heavy":"250ug+","Light":"50-100ug","Strong":"175-225ug"}},"formatted_duration":{"_unit":"hours","value":"9-14"},"formatted_effects":["visual distortions","a sense of childlike wonder","brightening of colors","racing thoughts","hue shifts","euphoria","anxiety","confusion"],"formatted_onset":{"_unit":"minutes","value":"45-90"},"links":{"experiences":"https://www.erowid.org/experiences/subs/exp_LSD.shtml","tihkal":"https://www.erowid.org/library/books_online/tihkal/tihkal26.shtml"},"name":"lsd","pretty_name":"LSD","properties":{"after-effects":"12-24 hours","aliases":["lsd-25","acid","cid","lucy"],"avoid":"marijuana (Can potentiate effects)","categories":["psychedelic","common"],"dose":"Oral Light: 50-100ug Common: 100-150ug Strong: 175-225ug Heavy: 250ug+ | Note: These doses are for pure LSD, note that tabs are often rather a lot weaker than they are advertised.","duration":"9-14 hours, varying with dosage (heavy doses can lead to much longer trips).","effects":"visual distortions, a sense of childlike wonder, brightening of colors,racing thoughts, hue shifts, euphoria, anxiety, confusion","half-life":"3-5 hours","marquis":"Olive black","onset":"45-90 minutes depending on ROA and stomach contents.","Oral":"Light: 50-100ug Common: 100-150ug Strong: 175-225ug Heavy 225ug+ | Note: These doses are for pure LSD, note that tabs are often rather a lot weaker than they are advertised.","summary":"LSD is a popular psychedelic with a relatively long history of use and research, and as such is known to be relatively safe despite its extremely high potency. It is the archetypical psychedelic to which all others are compared, and remains in popular usage."},"pweffects":{"8A Geometry - Exposure to semantic concept network":"https://psychonautwiki.org/wiki/8A_Geometry_-_Exposure_to_semantic_concept_network","Acuity enhancement":"https://psychonautwiki.org/wiki/Acuity_enhancement","After images":"https://psychonautwiki.org/wiki/After_images","Analysis enhancement":"https://psychonautwiki.org/wiki/Analysis_enhancement","Auditory distortion":"https://psychonautwiki.org/wiki/Auditory_distortion","Auditory enhancement":"https://psychonautwiki.org/wiki/Auditory_enhancement","Auditory hallucinations":"https://psychonautwiki.org/wiki/Auditory_hallucinations","Autonomous entities":"https://psychonautwiki.org/wiki/Autonomous_entities","Bodily control enhancement":"https://psychonautwiki.org/wiki/Bodily_control_enhancement","Colour enhancement":"https://psychonautwiki.org/wiki/Colour_enhancement","Colour shifting":"https://psychonautwiki.org/wiki/Colour_shifting","Conceptual thinking":"https://psychonautwiki.org/wiki/Conceptual_thinking","Creativity enhancement":"https://psychonautwiki.org/wiki/Creativity_enhancement","Déjà vu":"https://psychonautwiki.org/wiki/D%C3%A9j%C3%A0_vu","Delusions":"https://psychonautwiki.org/wiki/Delusions","Depth perception distortions":"https://psychonautwiki.org/wiki/Depth_perception_distortions","Drifting":"https://psychonautwiki.org/wiki/Drifting","Emotion enhancement":"https://psychonautwiki.org/wiki/Emotion_enhancement","External hallucinations":"https://psychonautwiki.org/wiki/External_hallucinations","Feelings of eternalism":"https://psychonautwiki.org/wiki/Feelings_of_eternalism","Feelings of interdependent opposites":"https://psychonautwiki.org/wiki/Feelings_of_interdependent_opposites","Feelings of self-design":"https://psychonautwiki.org/wiki/Feelings_of_self-design","Geometry":"https://psychonautwiki.org/wiki/Geometry","Immersion enhancement":"https://psychonautwiki.org/wiki/Immersion_enhancement","Increased heart rate":"https://psychonautwiki.org/wiki/Increased_heart_rate","Increased libido":"https://psychonautwiki.org/wiki/Increased_libido","Internal hallucinations":"https://psychonautwiki.org/wiki/Internal_hallucinations","Laughter":"https://psychonautwiki.org/wiki/Laughter","Magnification":"https://psychonautwiki.org/wiki/Magnification","Memory suppression":"https://psychonautwiki.org/wiki/Memory_suppression","Multiple thought streams":"https://psychonautwiki.org/wiki/Multiple_thought_streams","Muscle spasms":"https://psychonautwiki.org/wiki/Muscle_spasms","Nausea":"https://psychonautwiki.org/wiki/Nausea","Novelty enhancement":"https://psychonautwiki.org/wiki/Novelty_enhancement","Pattern recognition enhancement":"https://psychonautwiki.org/wiki/Pattern_recognition_enhancement","Personal bias suppression":"https://psychonautwiki.org/wiki/Personal_bias_suppression","Personal meaning enhancement":"https://psychonautwiki.org/wiki/Personal_meaning_enhancement","Personality regression":"https://psychonautwiki.org/wiki/Personality_regression","Perspective alterations":"https://psychonautwiki.org/wiki/Perspective_alterations","Perspective distortions":"https://psychonautwiki.org/wiki/Perspective_distortions","Physical euphoria":"https://psychonautwiki.org/wiki/Physical_euphoria","Pupil dilation":"https://psychonautwiki.org/wiki/Pupil_dilation","Recursion":"https://psychonautwiki.org/wiki/Recursion","Scenarios and plots":"https://psychonautwiki.org/wiki/Scenarios_and_plots","Scenery slicing":"https://psychonautwiki.org/wiki/Scenery_slicing","Settings, sceneries, and landscapes":"https://psychonautwiki.org/wiki/Settings,_sceneries,_and_landscapes","Simultaneous emotions":"https://psychonautwiki.org/wiki/Simultaneous_emotions","Spirituality enhancement":"https://psychonautwiki.org/wiki/Spirituality_enhancement","Spontaneous tactile sensations":"https://psychonautwiki.org/wiki/Spontaneous_tactile_sensations","Stimulation":"https://psychonautwiki.org/wiki/Stimulation"},"sources":{"_general":["Agonistic activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors - http://www.ncbi.nlm.nih.gov/pubmed/9600588","Alterations in responses to LSD in humans associated with chronic administration of tricyclic antidepressants, monoamine oxidase inhibitors or lithium... - http://www.ncbi.nlm.nih.gov/pubmed/8788508","Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans - http://www.ncbi.nlm.nih.gov/pubmed/8726753","LSD toxicity: a suspected cause of death - http://www.ncbi.nlm.nih.gov/pubmed/845494","Influence of naloxone on the effects of LSD in monkeys. - http://www.ncbi.nlm.nih.gov/pubmed/6527737","Coma, hyperthermia and bleeding associated with massive LSD overdose. A report of eight cases - http://www.ncbi.nlm.nih.gov/pubmed/4816396","Ascorbic acid antagonizes the behavioural effects of LSD in cats - http://www.ncbi.nlm.nih.gov/pubmed/2868111","Illicit use of LSD or psilocybin, but not MDMA or nonpsychedelic drugs, is associated with mystical experiences in a dose-dependent manner - http://www.ncbi.nlm.nih.gov/pubmed/23457892","New Onset LSD Flashback Syndrome Triggered by the Initiation of SSRIs - http://www.ncbi.nlm.nih.gov/pubmed/21603479","LSD and tryptamine effects on sleep/wakefulness and electrocorticogram patterns in intact cats - http://www.ncbi.nlm.nih.gov/pubmed/210478","Characterization of behavioral and endocrine effects of LSD on zebrafish - http://www.ncbi.nlm.nih.gov/pubmed/20561961","Drug dreams in mescaline and LSD addiction - http://www.ncbi.nlm.nih.gov/pubmed/20163393","Response of cluster headache to psilocybin and LSD - http://www.ncbi.nlm.nih.gov/pubmed/16801660","LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents - https://www.ncbi.nlm.nih.gov/pubmed/7965440","Metabolism of lysergic acid diethylamide (LSD) to 2-oxo-3-hydroxy LSD (O-H-LSD) in human liver microsomes and cryopreserved human hepatocytes - https://www.ncbi.nlm.nih.gov/pubmed/11043658","LSD-induced entropic brain activity predicts subsequent personality change. - https://www.ncbi.nlm.nih.gov/pubmed/27151536"]}}]}