{"err":null,"data":[{"aliases":["4-mmc","meow","m-cat","4-methylmethcathinone","4mmc"],"categories":["stimulant","research-chemical","habit-forming","empathogen"],"combos":{"dextromethorphan":{"note":"Risk of serotonin syndrome as both drugs raise serotonin levels. In addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.","sources":[{"author":"J Kehr,  F Ichinose,  S Yoshitake,  M Goiny,  T Sievertsson,  F Nyberg,  T Yoshitake","title":"Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats","url":"https://doi.org/10.1111/j.1476-5381.2011.01499.x"},{"author":"Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein","title":"4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse","url":"https://doi.org/10.1124/jpet.111.184119 "},{"author":"Anna R. Schwartz, Anthony F. Pizon & Daniel E. Brooks","title":"Dextromethorphan-induced serotonin syndrome","url":"https://doi.org/10.1080/15563650701668625"},{"author":"DrugBank","title":"Dextromethorphan","url":"https://go.drugbank.com/drugs/DB00514"},{"author":"Henderson MG, Fuller RW","title":"Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats","url":"https://doi.org/10.1016/0006-8993(92)91144-4"},{"author":"Reissig CJ, Carter LP, Johnson MW, Mintzer MZ, Klinedinst MA, Griffiths RR","title":"High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens ","url":"https://doi.org/10.1007/s00213-012-2680-6"},{"author":"Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.","title":"Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat ","url":"https://doi.org/10.1016/j.toxlet.2011.10.010"}],"status":"Dangerous"}},"formatted_aftereffects":{"_unit":"hours","value":"6-24"},"formatted_dose":{"Insufflated":{"Common":"20-80mg","Heavy":"125mg+","Light":"15-25mg","Strong":"75-125mg"},"Oral":{"Common":"100-200mg","Heavy":"300mg+","Light":"50-100mg","Strong":"150-300mg"}},"formatted_duration":{"_unit":"hours","value":"2-3"},"formatted_effects":["Generally described as being more intense of a stimulant than MDMA but with somewhat less of an empathogenic feel"],"formatted_onset":{"_unit":"minutes","value":"15-45"},"links":{"experiences":"https://www.erowid.org/experiences/subs/exp_4Methylmethcathinone.shtml"},"name":"mephedrone","pretty_name":"Mephedrone","properties":{"after-effects":"6-24 hours","aliases":["4-mmc","meow","m-cat","4-methylmethcathinone","4mmc"],"categories":["stimulant","research-chemical","habit-forming","empathogen"],"detection":"Mixed reports on whether the drug shows positive on standard drug tests.","dose":"Oral  Light: 50-100mg Common: 100-200mg Strong: 150-300mg Heavy: 300mg+ | Insufflated  Light: 15-25mg Common: 20-80mg Strong: 75-125mg Heavy: 125mg+","duration":"2-3 hours","effects":"Generally described as being more intense of a stimulant than MDMA but with somewhat less of an empathogenic feel.","onset":"15-45 minutes","summary":"A shortlived euphoric stimulant, developed as an analogue of MDMA, which was extremely popular in the research chemical scene before being banned. Commonly seen on street markets but rarer online. Very strong urge to redose compulsively."},"pweffects":{"Analysis enhancement":"https://psychonautwiki.org/wiki/Analysis_enhancement","Anxiety":"https://psychonautwiki.org/wiki/Anxiety","Body odor alteration":"https://psychonautwiki.org/wiki/Body_odor_alteration","Cognitive euphoria":"https://psychonautwiki.org/wiki/Cognitive_euphoria","Cognitive fatigue":"https://psychonautwiki.org/wiki/Cognitive_fatigue","Compulsive redosing":"https://psychonautwiki.org/wiki/Compulsive_redosing","Dehydration":"https://psychonautwiki.org/wiki/Dehydration","Depression":"https://psychonautwiki.org/wiki/Depression","Difficulty urinating":"https://psychonautwiki.org/wiki/Difficulty_urinating","Disinhibition":"https://psychonautwiki.org/wiki/Disinhibition","Ego inflation":"https://psychonautwiki.org/wiki/Ego_inflation","Empathy, love, and sociability enhancement":"https://psychonautwiki.org/wiki/Empathy,_love,_and_sociability_enhancement","Increased blood pressure":"https://psychonautwiki.org/wiki/Increased_blood_pressure","Increased heart rate":"https://psychonautwiki.org/wiki/Increased_heart_rate","Increased libido":"https://psychonautwiki.org/wiki/Increased_libido","Increased perspiration":"https://psychonautwiki.org/wiki/Increased_perspiration","Irritability":"https://psychonautwiki.org/wiki/Irritability","Motivation enhancement":"https://psychonautwiki.org/wiki/Motivation_enhancement","Spontaneous tactile sensations":"https://psychonautwiki.org/wiki/Spontaneous_tactile_sensations","Stimulation":"https://psychonautwiki.org/wiki/Stimulation","Tactile enhancement":"https://psychonautwiki.org/wiki/Tactile_enhancement","Teeth grinding":"https://psychonautwiki.org/wiki/Teeth_grinding","Thought acceleration":"https://psychonautwiki.org/wiki/Thought_acceleration","Thought deceleration":"https://psychonautwiki.org/wiki/Thought_deceleration","Thought disorganization":"https://psychonautwiki.org/wiki/Thought_disorganization","Time distortion":"https://psychonautwiki.org/wiki/Time_distortion","Vasoconstriction":"https://psychonautwiki.org/wiki/Vasoconstriction","Vibrating vision":"https://psychonautwiki.org/wiki/Vibrating_vision","Wakefulness":"https://psychonautwiki.org/wiki/Wakefulness"},"sources":{"_general":["Mephedrone toxicity has been clinically associated with seizures - http://emj.bmj.com/content/28/4/280.short"]}}]}