{"err":null,"data":[{"aliases":["oxy","oxycontin","percocet","oxynorm"],"categories":["opioid","habit-forming","depressant","common"],"dose_note":" Note: Dosages reflect that, while nasal bioavailability (BA) may be less than oral BA, nasal administration causes an additional 'rush' (due to quicker onset); this may lead to a subjective experience of greater strength than an equivalent oral dose.","formatted_aftereffects":{"_unit":"hours","value":"1-24"},"formatted_dose":{"Insufflated":{"Common":"7.5-15mg","Light":"2.5-7.5mg","Strong":"15-25mg"},"Oral":{"Common":"10-25mg","Light":"2.5-10mg","Strong":"25-40mg"}},"formatted_duration":{"_unit":"hours","Insufflated":"3-5","Intravenous":"3-5","Oral_ER":"6-8","Oral_IR":"4-6"},"formatted_effects":["Pain relief","Respiratory depression","Sedation","Constipation","Cough suppression","Decreased libido","Difficulty urinating","Itchiness","Nausea","Pupil constriction","Stomach cramps","Appetite suppression","Euphoria","Anxiety suppression","Dream potentiation"],"formatted_onset":{"_unit":"minutes","Insufflated":"2-5","Intravenous":"0-1","Oral_ER":"40","Oral_IR":"20"},"name":"oxycodone","pretty_name":"Oxycodone","properties":{"after-effects":"1-24 hours.","aliases":["oxy","oxycontin","percocet","oxynorm"],"bioavailability":"Oral 60-87% | Insufflated 55-70%","categories":["opioid","habit-forming","depressant","common"],"detection":"3-5 days for minimal use, 5-8 for regular use.","dose":"Oral Light: 2.5-10mg  Common: 10-25mg  Strong: 25-40mg | Insufflated Light: 2.5-7.5mg  Common: 7.5-15mg  Strong: 15-25mg | Note: Dosages reflect that, while nasal bioavailability (BA) may be less than oral BA, nasal administration causes an additional 'rush' (due to quicker onset); this may lead to a subjective experience of greater strength than an equivalent oral dose.","duration":"Oral_IR: 4-6 hours | Oral_ER: 6-8 hours. | Insufflated: 3-5 hours. | IV: 3-5 hours.","effects":"Pain relief, Respiratory depression, Sedation, Constipation, Cough suppression, Decreased libido, Difficulty urinating, Itchiness, Nausea, Pupil constriction, Stomach cramps, Appetite suppression, Euphoria, Anxiety suppression, Dream potentiation.","half-life":"2-4 hours","marquis":"Pale violet","onset":"Oral_IR: 20 minutes | Oral_ER: 40 minutes | Insufflated: 2-5 minutes | IV: 0-1 minutes","potentiators":"Avoid grapefruit juice, alcohol, and diphenhydramine. These products may react negatively and cause an overdose. Also do not consume more than 4g APAP (acetaminophen) in a day.","summary":"A semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas, and carries a high potential for addiction. Reported as being a little more 'stimulating' than other opioids."},"pweffects":{"Anxiety suppression":"https://psychonautwiki.org/wiki/Anxiety_suppression","Cognitive euphoria":"https://psychonautwiki.org/wiki/Cognitive_euphoria","Constipation":"https://psychonautwiki.org/wiki/Constipation","Cough suppression":"https://psychonautwiki.org/wiki/Cough_suppression","Difficulty urinating":"https://psychonautwiki.org/wiki/Difficulty_urinating","Internal hallucinations":"https://psychonautwiki.org/wiki/Internal_hallucinations","Itchiness":"https://psychonautwiki.org/wiki/Itchiness","Nausea":"https://psychonautwiki.org/wiki/Nausea","Pain relief":"https://psychonautwiki.org/wiki/Pain_relief","Physical euphoria":"https://psychonautwiki.org/wiki/Physical_euphoria","Pupil constriction":"https://psychonautwiki.org/wiki/Pupil_constriction","Respiratory depression":"https://psychonautwiki.org/wiki/Respiratory_depression","Sedation":"https://psychonautwiki.org/wiki/Sedation","Stomach cramps":"https://psychonautwiki.org/wiki/Stomach_cramps"},"sources":{"_general":["Controlled-release oxycodone-induced seizures. - http://www.ncbi.nlm.nih.gov/pubmed/16368452","Grapefruit juice enhances the exposure to oral oxycodone. - http://www.ncbi.nlm.nih.gov/pubmed/20406214","Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain. - http://www.ncbi.nlm.nih.gov/pubmed/20670044","Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain. - http://www.ncbi.nlm.nih.gov/pubmed/7818116","Differential effects of food on the bioavailability of controlled-release oxycodone tablets and immediate-release oxycodone solution. - http://www.ncbi.nlm.nih.gov/pubmed/8901078","Oxycodone is found to suppress sodium currents in the thalamic regions of the brain at high doses and is an effect that is independent of the MOR/u-opioid recepter and therefore this mechanism is not blocked by the use of naloxone - http://www.sciencedirect.com/science/article/pii/S0304394009001268","Oxycodone is found to have longer lasting more efficient effects on pain due to neuropathy because of having GABA-B agonist properties -http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091297","Oxycodone when paired with an ultra low dose of naltrexone, an opioid antagonist, oxycodone has a longer duration of pain relief - http://www.sciencedirect.com/science/article/pii/S1526590005004128","Oxycodone has been found to be an effective treatment for restless leg syndrome - http://europepmc.org/abstract/med/8341893","Pharmacokinetics of oxycodone done orally and intramuscularly http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.1992.tb04090.x/abstract"]}}]}