Index > Factsheets > Clomethiazole


SummaryStructurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.
DoseOral Threshold: 100mg Light: 100-150mg Common: 150-200mg Heavy: 200mg+
Onset15-40 minutes.
Duration5-8 hours.
WarningThe normal amount in capsules is 192mg's. Treat this more as a barbiturate than a benzodiazepine, as the toxicology for this substance is rather lacking.
EffectsAnxiolytic, Sedative, Muscle Relaxant, Amnesia, Dystaxia, Hypnotic.
After-effects1-16 hours.