Index > Factsheets > Codeine


SummaryCodeine is a weaker opioid used to treat mild to moderate pain and to relieve cough. In many countries it is available over the counter in combination with paracetamol, which can easily be extracted to retrieve near-pure codeine. For this reason, it is used widely as a recreational opioid. It is metabolised into morphine in the body at a rate of 5% mg for mg.
DoseOral Light: 50-100mg Common: 100-150mg Heavy: 150-200mg
NOTE: The ceiling effect differs from person to person, but it seems to fall between 400-600mg
Onset30-45 minutes
Duration3-6 hours
AvoidPeople seeking codeine experiences from medications that contain acetaminophen (paracetamol) may be putting themselves at risk for acetaminophen-related complications such as liver damage.
MarquisVery dark purple
BioavailabilityOral 90% | Rectal 90%
EffectsEuphoria, Dry Mouth, Mood lift, Itchiness, Relaxant, Constipation, Pupil constriction, Analgesia.
WarningYou must only use this drug orally due to the risk of severe immune system responses. It needs to pass through the liver to be activated anyway so IV, nasal, plugging etc do not offer an advantage
After-effects1-12 hours.