Index > Factsheets > Cyclizine


SummaryFirst generation antihistamine and anticholinergic drug used to combat nausea and vomiting. Causes drowsiness. Like most antihistamines in high doses it induces delirium and vivid realistic hallucinations. Probably uncomfortable and not enjoyable.
DoseCommon: 25-50mg's.
Onset10-30 minutes.
DurationOral 4-8 hours.
Side-effectsdrowsiness, dry mouth, headache, psychomotor impairment, urinary retention, blurred vision, dermatitis, and gastrointestinal disturbances
After-effects14 - 16 hours
ChemistryIUPAC: 1-benzhydryl-4-methyl-piperazine | Formula: C18H22N2 | Molecular Mass: 266.381 g/mol | Water Solubility: 1000 mg/L (25 °C)
PharmacodynamicsH1 receptor inverse agonist; mACh receptor antagonist