Index > Factsheets > Ephedrine


SummaryEphedrine is a sympathomimetic amine commonly used as a stimulant, concentration aid, decongestant, appetite suppressant, and to treat hypotension associated with anaesthesia. A methamphetamine analogue and commonly used in the production of methamphetamine.
DoseOral Threshold: 5-10mg Light: 10-20mg Common: 20-30mg Strong: 30-50mg Heavy: 50mg+
Onset5-20 minutes.
Duration3 - 6 hours
Adverse-effectsTachycardia, cardiac arrhythmias, angina pectoris, vasoconstriction with hypertension, flushing, sweating, acne vulgaris, nausea, decreased urination, difficulty urinating, restlessness, confusion, insomnia, mild euphoria, mania/hallucinations, delusions, formication, dyspnea, pulmonary edema, dizziness, headache, tremor, hyperglycemic reactions, and dry mouth
ContraindictionsClosed-angle glaucoma, phaeochromocytoma, asymmetric septal hypertrophy (idiopathic hypertrophic subaortic stenosis), concomitant or recent (previous 14 days) monoamine oxidase inhibitor (MAOI) therapy, general anaesthesia with halogenated hydrocarbons (particularly halothane), tachyarrhythmias or ventricular fibrillation, and hypersensitivity to ephedrine
PharmacologyNDRA (Norepinephrine-Dopamine Releasing Agent)
PharmacokineticsBioavailability: 85% | Metabolism: minimal hepatic | Excretion: 22 - 99% renal
LegalAustralia: Prescription Only (S4) | Canada: Schedule VI | United Kingdom: P | United States: List I OTC
After-effects1-8 hours.