↳ Index > Factsheets > Midazolam
| Midazolam | Info |
|---|
| Summary | A common hypnotic, sedative and anxiolytic benzodiazepine. High doses may cause amnesia and loss of inhibitions. Unusually, it is water soluble, and commonly used as a premedication for sedation as the solubility makes it better for IV use than other benzodiazepines. |
| Dose | Oral Low: 5-10mg's Common: 10-15mg's Strong: 15-30mg. Insufflated Low: 3-7mg's Common: 7-15mg Strong: 15-25mg's. Rectal Low: 3-7mg's Common: 7-15mg's Strong:15-25mg's Intravenous Low: 2.5-5mg's Common: 5-10mg's Strong: 10-20mg's Intramuscular Low: 3-5mg's Common: 5-12mg's Strong: 12-25mg's. |
| Onset | oral 10-40 minutes Insufflated: 1-5 minutes Rectal: 15-25 minutes. IV: 0-1 minutes IM: 10-20 minutes. |
| Duration | 4-8 hours. |
| Avoid | All other CNS depressants. |
| Categories | benzodiazepine habit-forming depressant |
| Effects | Anxiolytic, Sedative, Muscle Relaxant, Amnesia, Dystaxia, Hypnotic. |
| Bioavailability | Oral [variable - significant first-pass metabolism] | Insufflated 55% | Intramuscular 90% |
| After-effects | 1-12 hours. |
| Bioavailability: | Oral [Highly variable] | Insufflated 55% | Intramuscular 90% |
| Dose_to_diazepam | Midazolam - 10mg ~=10mg Diazepam. |