Index > Factsheets > Oxycodone


SummaryA semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas, and carries a high potential for addiction. Reported as being a little more 'stimulating' than other opioids.
DoseOral Light: 2.5-10mg Common: 10-25mg Strong: 25-40mg
Insufflated Light: 2.5-7.5mg Common: 7.5-15mg Strong: 15-25mg
Note: Dosages reflect that, while nasal bioavailability (BA) may be less than oral BA, nasal administration causes an additional 'rush' (due to quicker onset); this may lead to a subjective experience of greater strength than an equivalent oral dose.
OnsetOral_IR: 20 minutes
Oral_ER: 40 minutes
Insufflated: 2-5 minutes
IV: 0-1 minutes
DurationOral_IR: 4-6 hours | Oral_ER: 6-8 hours. | Insufflated: 3-5 hours. | IV: 3-5 hours.
PotentiatorsAvoid grapefruit juice, alcohol, and diphenhydramine. These products may react negatively and cause an overdose. Also do not consume more than 4g APAP (acetaminophen) in a day.
Detection3-5 days for minimal use, 5-8 for regular use.
MarquisPale violet
BioavailabilityOral 60-87% | Insufflated 55-70%
Half-life2-4 hours
After-effects1-24 hours.
EffectsPain relief, Respiratory depression, Sedation, Constipation, Cough suppression, Decreased libido, Difficulty urinating, Itchiness, Nausea, Pupil constriction, Stomach cramps, Appetite suppression, Euphoria, Anxiety suppression, Dream potentiation.