Index > Factsheets > Quetiapine


SummaryAn atypical antipsychotic medication under the brand name Seroquel. Also used to treat insomnia and mood swings. This drug is very sedating and can stop/slow down psychedelic drug trips. Infrequently abused.
DoseOral Light: 25mg-50mg Common: 50mg-150mg Strong: 150mg-300mg Heavy: 300mg-800mg
OnsetOral IR: 15-30 minutes. Oral XR: 30-60 minutes.
Duration7-12 hours.
After-effectsCan last up to 24 hours after one use.
Adverse-effectsdizziness, fatigue, extrapyramidal symptoms, increased diastolic blood pressure, increased triglycerides, increased total cholesterol, increased appetite, constipation, dry mouth, headache, and somnolence
Drug-contradictionsapomorphine, bromocriptine, cabergoline, carbamazepine, cimetidine, clarithromycin, dabrafenib, dopamine, erythromycin, idelalisib, itraconazole, ivacaftor, ketoconazole, levodopa, lisuride, mefloquine, methyldopa, nefazodone, ondansetron, panobinostat, pramipexole, rifabutin, rifampin, ropinirole, sodium oxybate, st. john's wort, vilanterol, and vemurafenib
Overdose-symptomssedation, hypotension, tachycardia, cardiac arrhythmia, coma, and death
PharmacologyD1, D2, D3, and D4 receptor antagonist; 5-HT1A receptor partial agonist; 5-HT2A, 5-HT2C, and 5-HT7 receptor antagonist; α1-adrenergic and α2-adrenergic receptor antagonist; H1 receptor antagonist; mACh receptor antagonist
Effectssedation, dizziness, fatigue, constipation, dry mouth, headache, appetite change, increased blood pressure
ChemistryIUPAC: 2-(2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy)ethanol | Formula: C21H25N3O2S | Molecular Mass: 383.5099 g/mol | Solubility in Water: 3.29 mg/mL (20 °C)
LegalAustralia: Prescription Only (S4) | United Kingdom: POM | United States: ?-only