Index > Factsheets > Tapentadol


SummaryAn opioid analgesic drug with potency somewhere between tramadol and morphine, and with a similar action to Tramadol. Also an adrenergic reuptake inhibitor. High addiction potential. Potential for respiratory depression in overdose. Should not be combined with depressants or stimulants.
DoseOral Light: 25-50mg Common: 50-75mg Strong: 75-150mg+
NOTE: Doses are for no tolerance. Insufflated administration is ineffective.
OnsetOral_IR: 20-40 minutes.
Oral_ER: 60-120 minutes.
DurationOral_IR: 3-5 hours | Oral_ER: 5-8 hours.
AvoidAll other CNS depressants
EffectsEuphoria, Dry Mouth, Mood lift, Itchiness, Relaxant, Constipation, Pupil constriction, Analgesia.
After-effects1-12 hours.