Index > Factsheets > Tramadol


SummaryA synthetic opioid analgesic, tramadol is used to treat moderate pain and can be considered a medium-strength opioid. Tramadol also has the unusual effect of being a serotonin releasing agent and a serotonin reuptake inhibitor, and as a consequence should not be taken in excess due to the risk of serotonin syndrome. Risk of seizures above 300mg doses.
DoseOral Light: 50-100mg Common: 100-250mg Heavy: 250-400mg
NOTE: Tramadol has a ceiling dose, where recreational effects are not increased. Risk of seizure at doses over 300mg. Tramadol decreases the seizure threshold, use extreme caution. Dosing insufflated is ineffective.
Onset1 hour first effects, reaching peak blood concentration at 4 hours.
Duration5-7 hours
Effectseuphoria, elevated mood, overall feeling of contentedness, itching, drowsiness, vomiting, urinary retention, nausea, constipation, risk of seizure above 300mg
Avoidbenzos, alcohol, and other opiates
BioavailabilityOral 68-72% | Rectal 77%
After-effects1-12 hours.