Index > Factsheets > Zopiclone


SummaryA nonbenzodiazepine sedative sleep aid (Z-drug), which can have hallucinogenic effects if taken while awake. Often causes users to have a metallic taste in the mouth for ~12h. Has been reported in some cases to cause certain users to black out, redose excessively and undertake dangerous activities such as driving.
DoseOral Threshold: 3.5mg Light: 3.5-5mg Common: 5-7.5mg Strong: 7.5-15mg Heavy: 15-22.5mg
Onset15 - 30 minutes (on empty stomach)
Duration3.5-9 hours
EffectsLethargy, tiredness, a dreamlike state while awake, can induce heavy sleep.
ContraindictionsLiver disease, myasthenia gravis, severe chronic bronchitis, emphysema, sleep apnea, thyroid gland abnormalities, trimipramine, caffeine, alcohol, erythromycin, itraconazole, rifampicin, phenytoin, carbamazepine, ketoconazole, sulfaphenazole, and nefazodone
ChemistryIUPAC: (RS)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate | Formula: C17H17ClN6O3 | Molecular Mass: 388.808 g/mol
PharmacologyGABA-A receptor positive allosteric modulator; Benzodiazepine receptor agonist
PharmacokineticsProtein Binding: 45 - 80% | Metabolism: various cytochrome P450 liver enzymes | Excretion: respiration (~50%) and urine (7 - 10 %)
LegalAustralia: Prescription Only (S4) | United Kingdom: Controlled Drug (POM) | United States: Schedule IV
After-effects1-12 hours.